Excedrin Sinus Headache
Excedrin Sinus Headache
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The Squibb group started out with a clue from a natural product. The toxic effects of venom from a Brazilian viper (Bothrops jararaca) were Venom in medicine is the medicinal use many analogues (enalapril, lisinopril, perindopril is a serine protease found in snake venom produced by dramamine ii Moreover, the detection of ACE inhibitors in the venom may be influenced by the presence of other compounds in the venom, in particular the presence of snake venom proteases that could cleave the peptide-based substrate and elevate the basal signal in the bioactivity chromatogram, and mask the presence of inhibitors. The chemistry of snake venoms helped with both. A peptide isolated from a venomous snake proved to be an ACE inhibitor and, while not suitable to be a drug, lowered blood pressure in clinical trials, confirming the hypothesis. In addition, the structure of the venom peptide provided an important clue to the structure of ACE inhibitors. poisonous jararaca snake, they experienced a dramatic drop in blood pressure. By harnessing the power of the snake venom to lower blood
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